Introduction & Objective: Ethics, as affected by factors, affects some affairs also. One of those affected by it, is human temperament as a physical subject. How to influence ethics on temperament is a positive and sometimes negative effect. In the paper, it is tried to study the way in which it affected the human temperament as mentioned in the Quranic verses and traditions as well as the views given by philosophers, scholars of ethics and medical sciences. In addition, the effect of some ethical states on the types of temperament will also be examined. Given that specialist research has not been done so far, people often do not consider the cause and the way of treating many physical illnesses and disorders that are caused by ethical issues and problems. This highlights the need to study the issue. The method of study in this research is descriptive and analytical based on library approach. The obtained information has been categorized and analyzed. This research will show that moral excellence leads to positive effects, ie, the creation of moderation in temperament, and in the face of misunderstandings and ethical problems, also causes negative effects.