The aim of the study is to investigate professional ethics in the country's universities and compare it with the world's top universities with an emphasis on effective teaching. The research sample is the top 100 universities in the world and 539 universities in Iran (full number). This research is qualitative and has employed the optimal examination of successful national and international experiences using comparative study. At present, in Iranian universities and even in the world's top universities, more attention is paid to the Charter of Professional Ethics. Universities that have professional ethics documentation with an emphasis on effective teaching do not have a specific unified approach to expressing its content. On the other hand, professional ethics and related documents in universities cause the unity of procedure in the implementation of ethics in universities. University presidents and administrators need to pay more attention to developing professional ethics documents for universities so that they can best achieve the main goal of universities, which is effective teaching.